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目的 观察后程递量加速超分割放射治疗食管癌的疗效。方法 常规分割组 34例 ,每周 4MVX线照射5次 2 .0Gy ,总疗程 7周照射 70Gy。后程递量加速超分割组 36例 ,放射前程为常规分割 ,每次 2 .0Gy。 4周照射 2 0次共 40Gy ,然后缩野 ,每周照射 5天 ,每天 2次 ,第 1周每次 1.3Gy,间隔 6小时以上 ,第 2周每次 1.5Gy ,间隔 6小时以上 ,2周照射 2 0次共 2 8Gy。总疗程 6周 ,总剂量 68Gy。结果 后程递量加速超分割放疗组 1、2、3年食管局部病灶控制率和生存率分别为 63.9%,5 8.3%,5 2 .8%和 69.4%,5 2 .8%,38.9%。常规分割组分别为 38.2 %,2 9.4%,2 6.5 %和 44 .1%,2 6.5 %,17.6%。后程递量加速超分割放疗组的局部控制率和生存率明显高于常规分割放疗组
Objective To observe the effect of late course accelerated hyperfractionation radiotherapy for esophageal cancer. Methods 34 patients were divided into 4 groups by 4 MVX lines for 2 times per week for 2 Gy, and the total course of irradiation was 70 Gy for 7 weeks. After the course of the amount of accelerated hyperfraction group of 36 patients, the conventional radiological anterior segment, each 2.0 Gy. 4 weeks irradiation 20 times a total of 40Gy, and then shrinking, 5 days a week, 2 times a day, the first week of each 1.3Gy, more than 6 hours interval, the second week of 1.5Gy each interval of 6 hours or more, 2 Zhou irradiation 20 times a total of 2 8Gy. The total course of 6 weeks, the total dose of 68Gy. Results The rate of postoperative esophagectomy in the superfractionated radiotherapy group was 63.9%, 8.3%, 5.28% and 69.4%, 52.8% and 38.9% respectively at 1, 2 and 3 years, . Conventional split groups were 38.2%, 2 9.4%, 2 6.5% and 44.1%, 2 6.5% and 17.6%, respectively. Posterior delivery accelerated hyperfractionation radiotherapy group, the local control rate and survival rate was significantly higher than the conventional radiotherapy group