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目的:在前期托里透毒法促进大鼠慢性胃溃疡黏膜修复的研究成果之上,从谷氨酰胺(Gln)因子,揭示托里透毒法促进慢性胃溃疡黏膜修复的机制。方法:采用乙酸烧灼型慢性胃溃疡模型,测定溃疡指数,光学显微镜观察病理,ELISA法测定Gln水平。结果:给药14天,体现托里透毒法各中药复方对乙酸烧灼型慢性胃溃疡均有不同程度抗溃疡和缩短溃疡修复时间,从而保护胃黏膜和促进溃疡修复作用,且以透脓散中剂量和低剂量作用较强。体现托里透毒法透脓散高剂量和透脓散中剂量均有增加胃黏膜Gln水平的作用。结论:透脓散高剂量和透脓散中剂量可能通过促进胃黏膜Gln的合成、表达,从而改善胃溃疡修复的营养状况,促进溃疡愈合,预防其复发。
OBJECTIVE: To study the mechanism of propofol to promote the mucosal repair of chronic gastric ulcer from the research results of propofol on the mucosal repair of chronic gastric ulcer in rats. Methods: The models of chronic gastric ulcer induced by acetic acid were used to measure the ulcer index. The pathological changes were observed with optical microscope. The level of Gln was determined by ELISA. Results: The administration for 14 days showed that all traditional Chinese medicine compounds of Torr toototoxicity had anti-ulcer and shortened ulcer repair time to acetic acid burn-type chronic gastric ulcer to protect gastric mucosa and promote ulcer repair, Medium dose and low dose strong role. Reflects Toluene toxin through the high dose of pus scattered and pus scattered in doses have increased the role of gastric mucosal Gln levels. Conclusion: The high dose of Thoroughbred suppository and the middle dose of Thoroughbred suppository may improve the nutritional status of gastric ulcer repair by promoting the synthesis and expression of Gln in gastric mucosa, promote the healing of ulcer and prevent its recurrence.