【摘 要】
：
Treatment for disorders of consciousness (DOCs) is still a Gordian knot.Evidence-based guidelines on the treatment of DOC patients are not currently available,while neuromodulation techniques are seen as a potential treatment.Multiple neuromodulation ther
【机 构】
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Department of Neurosurgery, PLA Army General Hospital,Beijing 100700, China;Department of Neurosurge
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Treatment for disorders of consciousness (DOCs) is still a Gordian knot.Evidence-based guidelines on the treatment of DOC patients are not currently available,while neuromodulation techniques are seen as a potential treatment.Multiple neuromodulation therapies have been applied.This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients.Both invasive and non-invasive brain stimulation is discussed.Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare.The efficacy of various such therapies remains a matter of debate.Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed,and new approaches are awaited.
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