【摘 要】
：
Fluoxetine,an anti-depressant drug,has recently been shown to provide neuroprotection in central nervous system injury,but its roles in subarachnoid hemorrhage (SAH) remain unclear.In this study,we aimed to evaluate whether fluoxetine attenuates early bra
【机 构】
：
Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an
论文部分内容阅读
Fluoxetine,an anti-depressant drug,has recently been shown to provide neuroprotection in central nervous system injury,but its roles in subarachnoid hemorrhage (SAH) remain unclear.In this study,we aimed to evaluate whether fluoxetine attenuates early brain injury (EBI) after SAH.We demonstrated that intraperitoneal injection of fluoxetine (10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier (BBB) disruption,microglial activation,and neuronal apoptosis in EBI after experimental SAH,as evidenced by the reduction of brain water content and Evans blue dye extravasation,prevention of disruption of the tight junction proteins zonula occludens-1,claudin-5,and occludin,a decrease of cells staining positive for Iba-1,ED-1,and TUNEL and a decline in IL-1β,IL-6,TNF-α,MDA,3-nitrotyrosine,and 8-OHDG levels.Moreover,fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model.These results indicated that fluoxetine has a neuroprotective effect after experimental SAH.
其他文献
Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication.Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins
Dysfunction of brain-derived arginine-vasopressin (AVP) systems may be involved in the etiology of autism spectrum disorder (ASD).Certain regions such as the hypothalamus,amygdala,and hippocampus are known to contain either AVP neurons or terminals and ma
The pathogenesis of the second major neurodegenerative disorder,Parkinson\'s disease (PD),is closely associated with the dysfunction of potassium (K+) channels.Therefore,PD is also considered to be an ion channel disease or neuronal channelopathy.Mounti
Injury to peripheral nerves can lead to neuropathic pain,along with well-studied effects on sensory neurons,including hyperexcitability,abnormal spontaneous activity,and neuroinflammation in the sensory ganglia.Neuropathic pain can be enhanced by sympathe
Increasing evidence suggests that spinal microglia regulate pathological pain in males.In this study,we investigated the effects of several microglial and astroglial modulators on inflammatory and neuropathic pain following intrathecal injection in male a
Toll-like receptors (TLRs) are well-known as patternrecognition receptors in the immune system for recognizing pathogen-associated and damage-associated molecular patterns [1].TLRs play an essential role in the innate and adaptive immune responses.To date
Astrocytes are closely associated with Alzheimer\'s disease (AD).However,their precise roles in AD pathogenesis remain controversial.One of the reasons behind the different results reported by different groups might be that astrocytes were targeted at d
Alzheimer\'s disease (AD) is the most common form of dementia among the elderly,characterized by amyloid plaques,neurofibrillary tangles,and neuroinflammation in the brain,as well as impaired cognitive behaviors.A sex difference in the prevalence of AD
Drosophila dEAAT2,a member of the excitatory amino-acid transporter (EAAT) family,has been described as mediating the high-affinity transport of taurine,which is a free amino-acid abundant in both insects and mammals.However,the role of taurine and its tr
Neurostimulation remarkably alleviates the symptoms in a variety of brain disorders by modulating the brain-wide network.However,how brain-wide effects on the direct and indirect pathways evoked by focal neurostimulation elicit therapeutic effects in an i