【摘 要】
：
The pathogenesis of the second major neurodegenerative disorder,Parkinson\'s disease (PD),is closely associated with the dysfunction of potassium (K+) channels.Therefore,PD is also considered to be an ion channel disease or neuronal channelopathy.Mounti
【机 构】
：
Collaborative Innovation Center for Brain Science, Department of Physiology, Shandong Provincial Col
论文部分内容阅读
The pathogenesis of the second major neurodegenerative disorder,Parkinson\'s disease (PD),is closely associated with the dysfunction of potassium (K+) channels.Therefore,PD is also considered to be an ion channel disease or neuronal channelopathy.Mounting evidence has shown that K+ channels play crucial roles in the regulations of neurotransmitter release,neuronal excitability,and cell volume.Inhibition of K+ channels enhances the spontaneous firing frequency of nigral dopamine (DA)neurons,induces a transition from tonic firing to burst discharge,and promotes the release of DA in the striatum.Recently,three K+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models:small conductance (SK)channels,A-type K+ channels,and Kv7/KCNQ channels.In this review,we summarize the physiological and pharmacological effects of the three K+ channels.We also describe in detail the laboratory investigations regarding K+ channels as a potential therapeutic target for PD.
其他文献
Sensory processing is strongly modulated by different brain and behavioral states,and this is based on the top-down modulation.In the olfactory system,local neural circuits in the olfactory bulb (OB) are innervated by centrifugal afferents in order to reg
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer\'s disease (AD),and insulinresistance is commonly seen in patients with Hhcy.Liraglutide (Lir),a glucagon-like peptide that increases the secretion and sensitivity of insulin,has a
ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.However,the neural mechanisms underlying this association are unknown.Given that ZNF804A upregulates the expression of COMT,we hypothesized that ZNF804A may influence brain a
Huntington\'s disease (HD) is an autosomal dominant degenerative disease that mainly encompasses movement,cognition,and behavioral symptoms.The apolipoprotein E (APOE) gene is thought to be associated with many neurodegenerative diseases.Here,we enrolle
Dear Editor,rnThe perirhinal cortex (PER) is conceptually important in the recognition memory,especially in familiarity discrimination,whereas the hippocampus is important for association and recollection [1].
Dear Editor,rnBecoming a mother is one of the most monumental experiences in a woman\'s lifetime.Women typically bear the primary caregiving responsibility for their infants,and they undergo numerous changes both mentally and physically,including behavi
The present study was aimed to evaluate restingstate functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls.Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched
Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication.Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins
Dysfunction of brain-derived arginine-vasopressin (AVP) systems may be involved in the etiology of autism spectrum disorder (ASD).Certain regions such as the hypothalamus,amygdala,and hippocampus are known to contain either AVP neurons or terminals and ma