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目的观察异甘草酸镁对肾综合征出血热(HFRS)患者血清指标的影响。方法采用随机对照方法观察异甘草酸镁治疗HFRS患者的临床疗效和血清游离甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,治疗组58例在综合治疗基础上加用异甘草酸镁100 mg,静脉滴注,每日1次,连用1周;对照组58例只用一般综合治疗。结果治疗组发热期、少尿期缩短,血尿素氮、肌酐、丙氨酸氨基转移酶、尿蛋白、血白细胞、血小板复常时间提前(P<0.05);治疗组血FT3和FT4下降较对照组减少(P<0.05),以FT3减少尤为明显,TSH无明显变化(P>0.05)。结论异甘草酸镁治疗肾综合征出血热患者有效,有缩短病程和抑制FT3和FT4水平下降的作用。
Objective To observe the effects of magnesium isoglycyrrhizinate on serum indexes of patients with hemorrhagic fever with renal syndrome (HFRS). Methods Randomized controlled clinical observation of magnesium glycyrrhizinate in patients with HFRS clinical efficacy and serum free thyroid acid (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH) levels, the treatment group of 58 patients on the basis of combined treatment Magnesium isoglycyrrhizin 100 mg, intravenous infusion, once daily for 1 week; control group of 58 cases only general general treatment. Results In the treatment group, the duration of oliguria was shortened, and the duration of blood urea nitrogen, creatinine, alanine aminotransferase, urine protein, white blood cell and platelet were advanced (P <0.05) (P <0.05), and the decrease of FT3 was more obvious than that of TSH (P> 0.05). Conclusion Isoglycate magnesium treatment of hemorrhagic fever with renal syndrome patients effective, shorten the duration and inhibit the decline of FT3 and FT4 role.