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用小鼠Ｌｅｗｉｓ肺癌、肝癌和肉瘤１８０移植瘤模型研究了牛磺酸棉酚和巴比妥棉酚的抑瘤活性，并用细胞集落形成法研究了牛磺酸棉酚对人胃癌ＢＧＣ８２３和人肝癌ＳＭＭＣ７７２１细胞系的细胞毒作用。结果表明，牛磺酸棉酚２０．０ｍｇ／ｋｇ（ｉｐ）对Ｌｅｗｉｓ肺癌抑瘤率为４２．５％～６９．２％，２５０ｍｇ／ｋｇ（ｉｐ）对肝癌腹水型小鼠生命延长率为７４．３％～１２０％，对肉瘤１８０抑瘤率为２９．５％～３４．７％，１０．０～１２．５ｍｇ／ｋｇ则无抗肿瘤作用。牛磺酸棉酚不同浓度与ＢＧＣ８２３和ＳＭＭＣ７７２１在３７℃作用２４ｈ用集落形成法检测结果表明，该药对两种人癌细胞系的细胞杀灭作用具有剂量依赖性，ＩＣ＿（５０）浓度分别为１９．０和２３．５ｍｇ／Ｌ巴比妥棉酚１００ｍｇ／ｋｇ（ｉｐ）对小鼠肝癌和肉瘤１８０治疗无效。
The antitumor activity of gossypol taurine and barbiturate was studied in mouse Lewis lung cancer, liver cancer and sarcoma 180 xenograft models. The effects of taurine gossypol on human gastric cancer BGC823 and human hepatocellular carcinoma Cytotoxicity of SMMC7721 cell line. The results showed that the tumor inhibition rate of taurine gossypol 20.0mg / kg (ip) on Lewis lung cancer was 42.5% -69.2%, and that of 250mg / kg ip was 74 .3% ~ 120%, sarcoma 180 inhibition rate of 29.5% to 34.7%, 10.0 ~ 12.5mg / kg no anti-tumor effect. Different concentrations of taurine gossypol and BGC823 and SMMC7721 at 37 ℃ 24h colony formation assay results show that the drug on the killing effect of two human cancer cell lines in a dose-dependent manner, IC 50 concentrations were 19.0 and 23.5 mg / L barbituluol 100 mg / kg (ip) on mouse liver cancer and sarcoma 180 treatment ineffective.