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目的探讨新疆大肠癌与肿瘤标志物的相关性。方法选取2013年7月至2016年7月间新疆医科大学第四附属医院收治的211例大肠癌患者的血清,采用电化学发光法测定血清中肿瘤标志物,分析不同性别、不同年龄、不同族别和不同部位以及发生肝转移前后肿瘤标志物的变化。分析单项检测和联合检测癌胚抗原(CEA)、CA125、CA724和CA153对大肠癌诊断的阳性率。结果女性患者血清中CA125水平较男性高,差异有统计学意义(P<0.05)。年龄≥70岁者血清中细胞角蛋白19片段(Cyfra21-1)的水平较<70岁者高,非汉族患者血清中CA153的水平较汉族高,差异均有统计学意义(均P<0.05)。大肠癌肝转移组患者血清中CA50、CEA、CA199和Cyfra21-1水平较未发生肝转移者高,差异均有统计学意义(均P<0.05)。联合检测多种肿瘤标志物可以提高检出阳性率,增加检测敏感性。结论肿瘤标志物可广泛用于肿瘤患者的早期诊断和预后判断,联合检测多种肿瘤标志物可提高敏感性,为大肠癌早期诊断提供依据。
Objective To investigate the correlation between colorectal cancer and tumor markers in Xinjiang. Methods Totally 211 sera from patients with colorectal cancer who were admitted to the Fourth Affiliated Hospital of Xinjiang Medical University from July 2013 to July 2016 were collected. The serum tumor markers were detected by electrochemiluminescence. The genotypes of different sexes, ages, Not different and different parts of liver metastasis and tumor markers before and after the change. The positive rates of single detection and combined detection of carcinoembryonic antigen (CEA), CA125, CA724 and CA153 in the diagnosis of colorectal cancer were analyzed. Results The level of serum CA125 in female patients was significantly higher than that in men (P <0.05). Serum cytokeratin 19 fragment (Cyfra21-1) was higher in patients than 70 years old as compared with those in patients <70 years old. The CA153 level in serum of non-Han patients was higher than Han nationality (all P <0.05) . The serum levels of CA50, CEA, CA199 and Cyfra21-1 in patients with liver metastasis from colorectal cancer were significantly higher than those without liver metastasis (all P <0.05). Combined detection of a variety of tumor markers can increase the positive rate and increase the detection sensitivity. Conclusion Tumor markers can be widely used in the early diagnosis and prognosis of cancer patients. Combined detection of multiple tumor markers can improve the sensitivity and provide the basis for the early diagnosis of colorectal cancer.