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目的：观察Ｌ－Ａｒｇ对肾血管性高血压所致心肌肥厚大鼠孤束核ＮＯＳ及主动脉、左室肌ＣａＭ含量的影响。方法：运用组织化学染色显示孤束核ＮＯＳ阳性神经元，并测定光密度作半定量分析，用生化方法测定主动脉和左室肌ＣａＭ活性。结果：８周后Ｌ－Ａｒｇ治疗组孤束核ＮＯＳ含量增加，主动脉及左室肌ＣａＭ活性较２Ｋ１Ｃ组和Ｌ－ＮＡＭＥ治疗组低。结论：Ｌ－Ａｒｇ治疗能逆转心肌肥厚，促进孤束核ＮＯＳ阳性神经元生成，并对主动脉及左室肌ＣａＭ产生积极影响。
Objective: To observe the effect of L-Arg on the content of CaM in NOS, aorta and left ventricular muscle of nucleus tractus solitarius induced by renovascular hypertensive rats. Methods: NOS positive neurons of nucleus tractus solitarius were detected by histochemical staining. The optical density was determined by semiquantitative analysis. The activity of CaM in the aorta and left ventricular muscle was measured by biochemical methods. Results: After 8 weeks, the content of NOS in nucleus tractus of L-Arg group increased, while the activity of CaM in aorta and left ventricle was lower than that of 2K1C group and L-NAME group. CONCLUSION: L-Arg treatment can reverse cardiac hypertrophy and promote the production of NOS positive neurons in the nucleus tractus of the solitary tract and positively affect CaM of the aorta and left ventricle.