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目的探讨网膜素-1与脑梗死合并颈动脉粥样硬化的关系。方法 50例脑梗死患者为CI组,50例颈动脉粥样硬化患者为AS组,50例脑梗死合并颈动脉粥样硬化患者为CI+AS组,50例同期体检健康者为对照组。采用ELISA法检测4组血清网膜素-1水平,并进行比较;采用析因分析法分析脑梗死与颈动脉粥样硬化主效应及二者交互作用;采用多元线性回归法分析血清网膜素-1水平与脑梗死及颈动脉粥样硬化相关性。结果 CI组[(251.63±20.77)μg/L]、AS组[(229.15±18.92)μg/L]和CI+AS组[(192.07±21.10)μg/L]血清网膜素-1水平明显低于对照组[(309.76±21.94)μg/L](P<0.05),CI+AS组血清网膜素-1水平明显低于CI组和AS组(P<0.05),AS组低于CI组(P<0.05);析因分析结果显示,脑梗死和颈动脉粥样硬化均能降低血清网膜素-1水平(P<0.05),脑梗死与颈动脉粥样硬化间存在交互效应显著(F=12.905,P=0.000),表现为协同作用;多元线性回归分析结果显示,血清网膜素-1水平与脑梗死和颈动脉粥样硬化呈负相关(P<0.01)。结论脑梗死和颈动脉粥样硬化患者血清网膜素-1水平明显降低,网膜素-1可作为脑梗死合并颈动脉粥样硬化的保护性预测因子。
Objective To investigate the relationship between retinol-1 and cerebral infarction with carotid atherosclerosis. Methods Fifty patients with cerebral infarction were CI group, 50 patients with carotid atherosclerosis were AS group, 50 patients with cerebral infarction and carotid atherosclerosis were CI + AS group, and 50 healthy subjects were in control group. The levels of serum retinin-1 in 4 groups were detected by ELISA and compared with each other. The main effect of cerebral infarction and carotid atherosclerosis and their interaction were analyzed by factorial analysis. The serum levels of serum retinin -1 levels and cerebral infarction and carotid atherosclerosis related. Results The level of serum retinin-1 in CI group [(251.63 ± 20.77) μg / L] [(229.15 ± 18.92) μg / L] and [192.07 ± 21.10 μg / L] in CI + AS group was significantly lower The level of serum retinin-1 in CI + AS group was significantly lower than that in CI group and AS group (P <0.05) in the control group [(309.76 ± 21.94) μg / L] (P <0.05) (P <0.05). The results of factorial analysis showed that both cerebral infarction and carotid atherosclerosis decreased the level of serum retinin-1 (P <0.05) and the interaction between cerebral infarction and carotid atherosclerosis was significant F = 12.905, P = 0.000). The results of multiple linear regression analysis showed that the level of serum retinin-1 was negatively correlated with cerebral infarction and carotid atherosclerosis (P <0.01). Conclusion The level of serum retinin-1 in patients with cerebral infarction and carotid atherosclerosis is significantly decreased. Overexpression of retinol-1 can be used as a protective predictor of carotid atherosclerosis in patients with cerebral infarction.