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鉴于花生四烯酸(AA)代谢物前列腺素(PG)和白三烯(LT)在感染性休克发病学中起重要作用,研究山莨菪碱(654-2)对AA代谢的影响有可能从一个方面阐明大剂量654—2的抗休克机理。有报道654—2可减少血小板形成血栓素B_2(TXB_2),在感染性休克动物早期给予654—2可降低血浆PG水平。然对于654-2与AA代谢间的确切关系迄今不明。作者发现654-2可拮抗乙酰胆碱和去甲肾上腺素引起的PG释放,能减少大鼠中性白细胞
In view of the important role of arachidonic acid (AA) metabolites, prostaglandin (PG) and leukotriene (LT), in the pathogenesis of septic shock, the impact of anisodamine (654-2) on AA metabolism may be One aspect elucidates the anti-shock mechanism of high-dose 654-2. It has been reported that 654-2 can reduce the formation of thromboxane B_2 (TXB_2) in platelets, and the early administration of 654-2 in septic shock animals can decrease plasma PG levels. However, the exact relationship between 654-2 and AA metabolism is unknown so far. The authors found that 654-2 can antagonize acetylcholine and norepinephrine-induced release of PG, can reduce rat neutrophils