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本文分析了正常鼠、矽肺鼠及汉防已甲素治疗的矽肺鼠肺组织及肺表面活性物质中主要磷脂成分的含量及磷脂构成比。结果表明矽肺鼠较正常鼠肺组织中主要磷脂成分含量有增高,汉甲治疗鼠较矽肺鼠主要磷脂成分量降低并且在肺组织中磷脂的构成比发生了改变,其原因主要是由于肺表面活性物质量的增减及磷脂构成比的改变所致。提出肺表面活性物质中饱和卵脂的含量可作为评价粉尘对肺脏的毒性及药物疗效观察的指标,而汉防已甲素是降低肺内脂类抑制肺纤维化进展较理想的药物。
This paper analyzed the content of main phospholipids and the composition ratio of phospholipids in the lung tissue and lung surfactant of the pneumoconiosis-treated mice. The results showed that the contents of main phospholipids in lung tissue of pupae mice were higher than those in normal rats. The amount of main phospholipids in rats treated with hanjia was lower than that in pups of pupae, and the composition ratio of phospholipids in lung tissues was changed. The reason was mainly due to lung surface activity. The increase or decrease of the substance quality and the change of the phospholipid composition ratio. It is proposed that the content of saturated lecithin in lung surfactant can be used as an index to evaluate the toxicity of dust to the lungs and the observation of drug efficacy. Hancopene is an ideal drug for reducing the progression of intralipid lipids to inhibit pulmonary fibrosis.