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对3个家族中氨基糖甙类抗生素中毒性耳聋患者的家族进行调查及分析，发现几种氨基糖甙类药物之间存在家族性和交叉易感性，即在有家族性耳毒性药物致聋的家族成员中，应用任何一种氨基糖甙类抗生素，都比一般人容易发生耳中毒；即使用量不大，也易引起严重后果，特别是年幼者。此种家族性与交叉易感性属常染色体显性遗传。提示临床医生用药前应仔细询问病史，特别是有母系家族耳聋史者应禁用氨基糖甙类全部抗生素，以预防子代耳聋的发生。
The family of patients with aminoglycoside antibiotic deafness in three families were investigated and analyzed and found to be familial and cross-susceptible among several aminoglycosides, namely, deafness caused by familial ototoxic drugs Family members, the application of any kind of aminoglycoside antibiotics, than the average person prone to ototoxicity; even if the amount is not large, but also easily lead to serious consequences, especially young. This familial and cross-susceptibility is autosomal dominant. Tips clinicians should carefully ask before taking medical history, in particular, have a family history of deafness should disable all aminoglycoside antibiotics to prevent the generation of deafness.