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分析内镜下切除治疗十二指肠非壶腹性黏膜病变的疗效。收集2016年1月—2019年6月于3所医院行内镜下切除治疗的58例十二指肠非壶腹性黏膜病变患者的内镜及病理资料进行回顾性分析。58例患者中，病变位于十二指肠球部27例(46.6%)，十二指肠降部(包括球降交界)31例(53.4%)；行内镜黏膜切除术治疗者46例(79.3%)，内镜黏膜下剥离术7例(12.1%)，内镜下预切开黏膜切除术5例(8.6%)；1例术中出血，1例术后2 d迟发性出血，1例病变残留，2例术后腹痛，无穿孔发生。内镜下治疗十二指肠非壶腹性黏膜病变是安全有效的。“,”To study the clinical effect of non-ampullary duodenal mucosal lesions treated by endoscopic resection. A retrospective analysis was performed on the data of 58 cases of duodenal non-ampullary mucosal lesions treated by endoscopic resection from January 2016 to June 2019 from 3 hospitals. Among 58 cases, 27 lesions (46.6%) were located in the duodenal bulb and 31 (53.4%) in the duodenal descending part (including the ball-drop boundary). Forty-six patients (79.3%) received endoscopic mucosal resection, 7 (12.1%) received endoscopic submucosal dissection and 5 (8.6%) received pre-cut endoscopic mucosal resection. Few postoperative complications were found except for 1 case of intraoperative bleeding, 1 case of delayed bleeding 2 days after surgery, 1 case of lesion residual and 2 cases of postoperative abdominal pain. No perforation occurred. Endoscopic treatment of non-ampullary duodenal mucosal lesions is safe and effective.