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目的观察中药复方金思维对散发性老年性痴呆(SAD)大鼠模型学习记忆的影响。方法采用双侧脑室注射微量链脲佐菌素(STZ)建立散发性AD大鼠模型,金思维分为3个不同剂量对模型大鼠进行3个月的治疗。利用Morris水迷宫检测大鼠空间学习记忆能力并与盐酸多奈哌齐进行比较。结果定位航行实验中,模型组大鼠平均逃避潜伏期和游泳距离较假手术组明显延长(P<0.05或P<0.01);金思维各剂量组和多奈哌齐组平均逃避潜伏期和游泳距离较模型组明显缩短(P<0.05或P<0.01)。空间探索实验中,模型组与假手术组比较,原平台象限活动时间明显缩短(P<0.01);金思维各剂量组与模型组比较,原站台象限活动时间明显延长(P<0.01);与多奈哌齐组相比无显著差异。结论金思维能够显著改善散发性SAD模型大鼠的学习记忆功能。
OBJECTIVE: To observe the effect of compound Chinese herbal formulae on learning and memory in sporadic senile dementia (SAD) rats. Methods Sporadic Alzheimer’s disease (SD) rat model was established by intracerebroventricular injection of streptozotocin (STZ). Golden thinking was divided into 3 different doses to treat model rats for 3 months. Morris water maze was used to test spatial learning and memory ability of rats and compared with donepezil hydrochloride. Results In the positioning navigation experiment, the average escape latency and swimming distance in the model group rats were significantly longer than that in the sham group (P<0.05 or P<0.01). The mean escape latency and swimming distance in the Jin thought group and the donepezil group were significantly longer than those in the model group. Shortened (P<0.05 or P<0.01). In the space exploration experiment, compared with the sham operation group, the activity time of the original platform quadrant was significantly shorter (P<0.01); compared with the model group, the activity time of the original platform quadrant was significantly prolonged (P<0.01); There was no significant difference in the donepezil group. Conclusion Jin thinking can significantly improve the learning and memory function of rats with sporadic SAD.