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背景对高血压前期进行早期干预可预防高血压的发病,非药物干预方法被认为是首选。目的探讨肌电生物反馈干预高血压前期的疗效及干预过程中脑电的非线性变化机制。方法40名高血压前期志愿者被分为生物反馈治疗组(n=20)和对照组(n=20)。生物反馈治疗组利用肌电生物反馈进行早期干预(10次,1次/3 d),并借助脑电非线性分析技术脑电近似熵(ApEn)对肌电生物反馈过程中脑功能的非线性机制进行探讨。对照组除不进行生物反馈外,其余同生物反馈治疗组。实验过程中,对照组有2例因学习紧张退出试验。结果肌电生物反馈治疗后受试者的基础肌电值明显降低。肌电生物反馈治疗可使收缩压下降10.4 mm Hg[治疗后(116.8±5.2)比治疗前(127.2±6.0)mm Hg,P<0.01],6月后随访的收缩压值为[(118.2±5.7)mm Hg],但舒张压下降不明显(与对照组比较,P>0.05)。肌电生物反馈过程中,生物反馈组脑电左右额极(Fp1、Fp2)、左右额(F3、F4)、左右颞前(F7、F8)导联的近似熵明显高于对照组(均P<0.05)。结论肌电生物反馈可有效地应用于高血压前期的早期干预,额前皮质可能是生物反馈过程中重要的功能整合部位。
Background Early intervention in prehypertension can prevent the onset of hypertension, and nonpharmacologic intervention is considered as the first choice. Objective To investigate the effect of electromyogram biofeedback on prehypertension and non-linear changes of EEG in the process of intervention. Methods Forty prehypertensive volunteers were divided into biofeedback group (n = 20) and control group (n = 20). In the biofeedback group, EMG biofeedback was used for early intervention (10 times, once / 3 days), and the nonlinearity of brain function in the EMG biofeedback process was evaluated by EEG nonlinear entropy (ApEn) Mechanism to explore. In addition to the control group without biological feedback, the rest with the biofeedback treatment group. During the experiment, two patients in the control group quit their study due to learning stress. The results of myoelectric biofeedback treatment subjects significantly lower myoelectricity. Myoelectric biofeedback therapy decreased systolic blood pressure by 10.4 mm Hg [(116.8 ± 5.2) vs 127.2 ± 6.0 mm Hg before treatment (P <0.01), and systolic blood pressure was (118.2 ± 5.7) mm Hg], but diastolic blood pressure was not significantly decreased (compared with the control group, P> 0.05). In the EMG biofeedback, the approximate entropy of the EEG (Fp1, Fp2), right and left forehead (F3, F4), left and right front (F7, F8) leads in the biofeedback group were significantly higher than those in the control group <0.05). Conclusion EMG biofeedback can be effectively applied to early intervention in prehypertension. Prefrontal cortex may be an important functional integration site in biofeedback.