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目的探讨老年胃肠道肿瘤患者采用腹腔免疫化疗的临床疗效和生活质量。方法将80例老年胃肠道肿瘤患者随机分为观察组(40例)和对照组(40例),观察组患者采用腹腔免疫化疗,对照组患者采用腹腔化疗,分析两组患者治疗前后消化病生存质量指数(GLQI)、治疗后卡氏行为状态评分(KPS)以及不良反应发生情况。结果观察组患者的好转率优于对照组(P<0.01)。观察组患者治疗后1周和4周的GLQI高于对照组(P<0.05),并且胃肠道反应和乏力的发生率低于对照组(P<0.05)。结论腹腔免疫化疗能够提高老年胃肠道肿瘤患者的疗效,增强患者的免疫功能,减少不良反应,改善患者的生活质量,可作为老年胃肠道肿瘤患者治疗的优选方案。
Objective To investigate the clinical efficacy and quality of life of elderly patients with gastrointestinal cancer using intraperitoneal immunochemotherapy. Methods 80 elderly patients with gastrointestinal cancer were randomly divided into the observation group (40 cases) and the control group (40 cases). The patients in the observation group received intraperitoneal chemotherapy and the control group received intraperitoneal chemotherapy. Quality of Life Index (GLQI), Post-Treatment Cardiac Behavior Status Score (KPS), and Adverse Reactions. Results The improvement rate of observation group was better than that of control group (P <0.01). The GLQI of observation group was higher than that of control group (P <0.05) at 1 week and 4 weeks after treatment, and the incidence of gastrointestinal reaction and fatigue was lower than that of control group (P <0.05). Conclusion Intraperitoneal immunochemotherapy can improve the efficacy of elderly patients with gastrointestinal cancer, enhance the patient’s immune function, reduce adverse reactions and improve the quality of life of patients, which can be used as the optimal treatment for elderly patients with gastrointestinal cancer.