论文部分内容阅读
目的探讨造血干细胞移植 (HSCT)治疗血液系统恶性疾病后患者常见的死亡原因。方法对采用 HSCT技术治疗的 2 4例患者的临床资料进行了回顾性分析。结果移植后死亡 10例 ,治愈或长期无病生存 14例。死亡原因为感染 4例 ,死亡时间 + 16～ + 2 68天 ,其中巨细胞病毒 (CMV)性间质性肺炎 (IP) 2例 ,败血症和肺部细菌、真菌、病毒混合性感染各 1例 ,病死率 16.7% (4 /2 4) ;肿瘤复发 6例 ,死亡时间 + 10 2～ + 741天 ,病死率 2 5 % (6/2 4)。结论感染和肿瘤复发是 HSCT后常见死亡原因 ,应积极防治感染和避免使用过量免疫抑制剂 ,预防移植物抗宿主病 (GVHD) ,以降低移植后病死率
Objective To investigate the common causes of death after hematopoietic stem cell transplantation (HSCT) in the treatment of hematological malignancies. Methods The clinical data of 24 patients treated with HSCT were retrospectively analyzed. Results 10 cases died after transplantation, and the cure or long-term disease-free survival in 14 cases. The cause of death was infection in 4 cases and death time + 16 to +2 68 days, including 2 cases of cytomegalovirus (CMV) interstitial pneumonia (IP), 1 case of mixed sepsis and pulmonary bacterial, fungal and viral infections , And the case fatality rate was 16.7% (4/24). Tumor recurrence occurred in 6 cases with a death time of 10 2 ~ + 741 days and a case fatality rate of 25% (6/2 4). Conclusions Infection and tumor recurrence are the common causes of death after HSCT. Prevention and treatment should be actively controlled and avoid excessive immunosuppressive agents to prevent graft-versus-host disease (GVHD) and to reduce the post-transplantation mortality