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吉西他滨是一个新型的脱氧胞苷拟似物和核苷还原酶抑制剂。吉西他滨属嘧啶类抗代谢肿瘤药物。即细胞周期特异性抗代谢类药物,主要作用于DNA合成期的肿瘤细胞,即S期细胞。在一定条件下,可以阻止G1期向S期的进展,具有抗瘤谱广、作用机制独特、毒性反应低、与其他化疗药物无交叉耐药等特点。本文就吉西他滨在胰腺癌治疗中的应用做一综述。1胰腺癌治疗的历史胰腺癌是临床常见的消化系统恶性肿瘤,占恶性肿瘤的1%-
Gemcitabine is a novel deoxycytidine mimetic and nucleoside reductase inhibitor. Gemcitabine pyrimidine anti-metabolic oncology drugs. The cell cycle-specific anti-metabolic drugs, the main role in the DNA synthesis of tumor cells, S phase cells. Under certain conditions, it can prevent the progress of G1 phase to S phase, and has the characteristics of broad anti-tumor spectrum, unique mechanism of action, low toxic reaction, no cross-resistance with other chemotherapeutic drugs and the like. This article reviews the application of gemcitabine in the treatment of pancreatic cancer. A history of pancreatic cancer treatment Pancreatic cancer is a common clinical malignant digestive system, accounting for 1% of malignant tumors -