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本实验运用镇静药理指标探讨了天麻钩藤饮等平肝熄风三方的体内药物动力学过程与参数。结果三方对小鼠自发活动均有一定的抑制作用,并呈显著的量效关系。天麻钩藤饮的最低起效剂量为032g/kg,相当于临床等效剂量的效应消退半衰期为094h,效应维持时间为437h,体存血药浓度达峰时间为181h;镇肝熄风汤相应为018g/kg,067h,436h,182h时;建瓴汤相应为006g/kg,049h,2101h(达峰时间未能测算出)。
In this study, sedative pharmacological parameters were used to explore the in vivo pharmacokinetics and parameters of Tianma Gouteng Yin et al. Results The three parties all had a certain inhibitory effect on the spontaneous activity of mice and showed a significant dose-effect relationship. The minimum effective dose of Tianma Gouteng Decoction was 032g/kg, which was equivalent to a clinically equivalent dose effect half-life of 094h, an effect maintenance time of 437h, and a body-preserving drug concentration peak time of 1. 81h; Zhengan Xifeng Decoction corresponds to 018g/kg, 067h, 436h, 182h; Jianshe Decoction corresponds to 006g/kg, 049h, 2101h (peak time Failed to measure out).