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目的：研究１－［２－（取代苯基）－２－（取代苯基甲硫基）乙基］－１Ｈ－１，２，４－三唑类化合物体外抗真菌活性，并初步探讨其构效关系。方法：选择８种临床致病真菌为试验菌，观察本类化合物对它们的体外抑菌活性。结果：所有化合物对８种试验菌的抑菌活性均优于或相当于氟康唑，大部分化合物的抑菌活性与硫康唑相当或更优。结论：本类化合物具有较强的广谱抗真菌活性，为深入开展广谱抗真菌药研究提供一条途径。
AIM: To study the antifungal activities of 1- [2- (substituted phenyl) -2- (substituted phenylmethylthio) ethyl] -1H-1,2,4-triazoles in vitro Effective relationship. Methods: Eight kinds of clinical pathogenic fungi were selected as experimental bacteria to observe the antibacterial activity of the compounds against them in vitro. Results: The antibacterial activities of all the compounds against 8 kinds of test bacteria were better than or equivalent to fluconazole. Most of the compounds showed the same or better antibacterial activity than that of sulconazole. Conclusion: The compounds have strong broad-spectrum antifungal activity, providing a way for further research on broad-spectrum antifungal drugs.