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23例结直肠癌术前未用消炎痛肛塞治疗的非用药组,外周静脉,局部灌流动静脉血的CD_4~+/CD_8~+值下降,SIL-2R、PGE_2水平升高,Dukes D期患者免疫功能显著异常。术前用消炎痛肛塞的用药组CD_4~+/CD_8~+值较非用药组增高,SIL-2R、PGE_2水平下降,Dukes C、D期患者局部灌流动静脉的各项免疫指标显著改善。说明结直肠癌患者免疫功能下降,晚期更受损,使用消炎痛肛塞可提高中晚期患者的局部免疫功能。
The value of CD_4~+/CD_8~+ in peripheral veins and local perfused venous blood was decreased in 23 patients with colorectal cancer who did not receive indomethacin anal occlusion before operation. The levels of SIL-2R and PGE2 increased, and Dukes D stage. The patient’s immune function was significantly abnormal. Compared with the non-drug group, the levels of CD_4~+/CD_8~+ increased preoperatively, and the levels of SIL-2R and PGE2 decreased in the drug group preoperatively treated with indomethacin and anal cannulation. The immune indexes of the local perfusion flow vein in patients with Dukes C and D were significantly improved. It shows that the immune function of patients with colorectal cancer is decreased, and the late stage is more impaired. The use of indomethacin and anal plugs can improve the local immune function in patients with advanced stage disease.