Bisarylmaleimides & the Corresponding Indolocarbazoles as Kinase Inhibitors

• 作 者: Scott E. Conner Harold B. Brooks Eileen Considine Jack A. Dempsey Margaret M. Faul Cathy Ogg Bharvin Patel Richard M. Schultz Charles D. Spencer Beverly Teicher Scott A. Watkins
• 机 构: Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis
• 出 处: 合成化学
• 发表日期: 2004年S1期
• 关键词: Kinase potent inhibited Cyclin substituted incidence cycle competitive progressi

Cyclin dependent kinases (CDKs) have recently raised considerable attention because of their central role in the regulation of cell cycle progression. A high incidence of genetic mutation of CDK substrates and deregulation of CDK modulators were found in

A high incidence of genetic mutation of CDK substrates and deregulation of CDK modulators were found in