论文部分内容阅读
目的 了解多发性骨髓瘤 (MultipleMyeloma ,MM)的免疫球蛋白 ,轻链κ .λ及其κ.λ比值之间的关系。方法 采用速率散射比浊法对 2 8例MM患者 ,30例正常人血清的Ig及轻链κ.λ进行检测 ,并计算轻链κ/λ比值。结果 2 8例MM患者中κ轻链升高 18例 ,λ轻链升高 10例 ,IgG多为升高 ,而IgA、IgM多为降低 ,其中IgG明显升高 14例 ,占 5 0 % ,IgA升高 4例 ,IgM升高仅 2例 ,8例IgG、IgA、IgM均低于正常 ,占 2 8.5 7% ,结果还显示 ,其中一轻链增高或正常 ,另一轻链则下降 ,κ异常升高 ,κ/λ值为 36 .2 5± 2 7.6 ,λ异常升高 ,κ/λ值则严重倒置 ,为 0 .16± 0 .14。结论 MM患者血清κ或λ轻链异常及其比值明显改变时 ,提示多发性骨髓瘤的诊断。
Objective To understand the relationship between multiple Myeloma (MM) immunoglobulins, light chain κ .λ and their κ.λ ratios. Methods The Ig and light chain kappa.lambda of serum from 28 normal subjects and 30 normal controls were detected by rate nephelometry and the ratio of light chain kappa/lambda was calculated. RESULTS: In the 28 cases of MM, there were 18 cases of κ light chain elevation, 10 cases of λ light chain elevation, and more IgG, while IgA and IgM were mostly decreased, and IgG was significantly elevated in 14 cases, accounting for 50%. IgA increased in 4 cases, IgM increased only 2 cases, 8 cases of IgG, IgA, IgM were lower than normal, accounting for 28.57%, the results also showed that one of the light chain increased or normal, and the other light chain decreased. Abnormal increase of κ, κ / λ value of 36.25 ± 2 7.6, λ abnormal increase, κ / λ value is a serious inversion, 0. 16 ± 0 .14. Conclusion When the serum κ or λ light chain abnormalities and their ratios change significantly in patients with MM, the diagnosis of multiple myeloma is suggested.