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本实验采用由二甲肼诱发的小鼠大肠癌模型观察柠檬桉叶挥发油的抗肿瘤作用,二甲肼诱发的小鼠大肠癌的组织学特点与人体大肠癌相似. 昆明种小鼠60只、雌性、体重18～22g、每周皮下注射DMH20mg/kg,连续20周.第20周末将存活的38只小鼠随机分为两组.治疗组每鼠每日灌胃给予2.5%柠檬桉叶挥发油悬液0.75ml,连给7天,间隔7天后再重复,共给药26次.对照组给予等体积生理盐水.第26周末处死全部小鼠.治疗组小鼠大肠肿瘤数显著低于对照(P<0.05).病理检查证实所有肿瘤均为分化良好的腺癌。治疗组肿瘤比对照组的小.浸润深度较对照组浅.
In this experiment, the anti-tumor effect of volatile oil of lemongrass was observed in a mouse model of colorectal cancer induced by dimethylhydrazine. The histological characteristics of colorectal cancer induced by dimethylhydrazine were similar to that of human colorectal cancer. 60 Kunming mice were used. Females, weighing 18 to 22 g, were subcutaneously injected with DMH 20 mg/kg every week for 20 weeks. At the end of the 20th week, 38 surviving mice were randomly divided into two groups. The treatment group was given intragastric administration of 2.5% lemongrass volatile oil per mouse per day. Suspension 0.75ml, continuous for 7 days, repeated 7 days later, a total of 26 doses. The control group was given an equal volume of saline. All mice were sacrificed at the end of the 26th week. The number of colorectal tumors in the treated group was significantly lower than the control group ( P<0.05). Pathological examination confirmed that all tumors were well-differentiated adenocarcinomas. The tumor in the treatment group was smaller than that in the control group. The depth of invasion was shallower than that of the control group.