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AIM:To evaluate the clinical value of plasma apolipoproteinA-I(Apo A-I)as a marker of fibrosis in children with chronichepatitis B(CHB).METHODS:Liver biopsy specimens from 49 children withCHB were evaluated by using Knodell index.Plasma ApoA-I level was measured after 12-h fasting.Student’s ttest,Spearman’s correlation test and receptor-operatingcharacteristic(ROC)curve were used for statisticalevaluation.RESULTS:Mean Apo A-I level of the patients was not differentfrom that of controls(P>0.05).Six(8.7%)children hadfibrosis score of more than 2(severe fibrosis).No differencein the level of mean plasma Apo A-I was found among childrenwith and without severe fibrosis(P>0.05).No correlationbetween Apo A-I level and fibrosis scores was found(P>0.05).The area under the ROC curve was 0.407±0.146 (P>0.05).CONCLUSION:Severe fibrosis is not common in childrenwith CHB and plasma Apo A-I level is not a reliable indicator offibrosis.
AIM: To evaluate the clinical value of plasma apolipoprotein A-I (Apo AI) as a marker of fibrosis in children with chronic hepatitis B (CHB). METHODS: Liver biopsy specimens from 49 children with CHB were evaluated by using Knodell index. level was measured after 12-h fasting. Student’s ttest, Spearman’s correlation test and receptor-operatingcharacteristic (ROC) curve were used for statisticalevaluation .RESULTS: Mean Apo AI level of the patients was not differentfrom that of controls (P> 0.05) (8.7%) children hadfibrosis score of more than 2 (severe fibrosis) .No differencein the level of mean plasma Apo AI was found among childrenwith and without severe fibrosis (P> 0.05) .No correlationbetween Apo AI level and fibrosis scores was found ( P> 0.05). The area under the ROC curve was 0.407 ± 0.146 (P> 0.05). CONCLUSION: Severe fibrosis is not common in children with CHB and plasma Apo AI level is not a reliable indicator offibrosis.