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目的:探讨地塞米松局部注射治疗突眼性甲状腺病(Graves病)的远期疗效。方法:将82例Graves病患者分为治疗组(用抗甲状腺药物治疗同时双侧甲状腺注射地塞米松)和对照组(单用抗甲状腺药物治疗),观察两组甲状腺变化、病情变化及复发等情况。结果:①治疗组甲状腺较对照组明显缩小,P<0.01;②治疗组抗甲状腺药物副作用(如皮疹、白细胞减少、肝功能损害等)较对照组发生少,甲亢症状减轻较对照组明显,P<0.05;③治疗组复发1例(2.4%),对照组复发9例(22%),甲状腺肿大程度与复发呈正相关。结论:局部注射地塞米松可促使肿大的甲状腺回缩,减轻甲亢症状,还可以减少抗甲状腺药物副作用,能显著降低复发率。
Objective: To investigate the long-term efficacy of local injection of dexamethasone in the treatment of Graves’s disease. Methods: Eighty-two patients with Graves’ disease were divided into treatment group (treated with anti-thyroid drug and bilateral thyroid injection of dexamethasone) and control group (treated with antithyroid drug alone), and the changes of thyroid gland, changes of disease and relapse Happening. Results: ① The thyroid gland of the treatment group was significantly smaller than that of the control group (P <0.01); ② The anti-thyroid drug side effects (such as skin rash, leukopenia, liver dysfunction, etc.) in the treatment group were less than those in the control group, <0.05; ③ The treatment group recurred in 1 case (2.4%), the control group recurred in 9 cases (22%), the degree of goiter was positively correlated with the recurrence. Conclusion: Local injection of dexamethasone can promote swelling of the thyroid gland, relieve the symptoms of hyperthyroidism, but also can reduce side effects of anti-thyroid drugs, can significantly reduce the recurrence rate.