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对照试验已证明用头孢噻肟治疗自发性细菌性腹膜炎(SBP)比氨苄青霉素及妥布霉素更好,因此该药已成为治疗此种感染的常用药物。但是,尚不清楚治疗开始时是否尚需腹腔注射或全身使用负荷剂量。本次研究的目的是:1).估计SBP患者静脉输注头孢噻肟后药物进入腹水的速度;2).测定药物的腹水/血清浓度比率;3).将药物腹水浓度与这些病人腹水中培养出的细菌的最小抑菌浓度进行对比。使用头孢噻肟2克每8小时1次静脉注射,治疗SBP患者41例次,于第一次用药后6、12、24、48、96小时分别取腹水及血标本予-70℃条件下贮存,之
Controlled trials have demonstrated that cefotaxime is better than ampicillin and tobramycin in the treatment of spontaneous bacterial peritonitis (SBP) and has become a commonly used drug for the treatment of this infection. However, it is unclear whether the dose at the onset of treatment required intraperitoneal or systemic use. The purpose of this study was to: 1) estimate the rate of drug entry into the ascites following intravenous cefotaxime in SBP patients; 2) determine the ascites / serum concentration ratio of the drug; and 3) compare the drug ascites concentration to ascites in these patients The minimum bacteriostatic concentration of cultured bacteria was compared. Cefotaxime 2 g once every 8 hours by intravenous injection, the treatment of SBP patients 41 cases, after the first dose of 6,12,24,48,96 hours were ascites and blood samples were stored at -70 ℃ , It