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乏氧细胞对射线所具有的较大抗性是对某些人类肿瘤进行放疗失效的主要原因。放射增敏剂的研究目的是为了提高射线在正常组织可耐受剂量下对肿瘤细胞的杀伤率,从而提高放疗效果。目前试用于临床的放射增散剂misoniizole(MISO)是一种硝基咪唑类化合物,由于其较强的神经毒性,限制了这种药物的推广和使用。为寻找新的低毒有效的放射增敏剂,我们设计并合成了一系列化合物,试验了它们对离体Hela-S_3细胞的放射增敏作用。
The greater resistance of hypoxic cells to radiation is a major cause of radiation therapy failure in certain human tumors. The purpose of radiosensitizer research is to improve the radiosensitivity to tumor cells in the tolerable dose of normal tissue, so as to improve the radiotherapy effect. At present, misoniizole (MISO), a clinical trial of radioactive dispersant, is a nitroimidazole compound that has limited the promotion and use of this drug because of its strong neurotoxicity. To search for a new, less toxic and effective radiosensitizer, we designed and synthesized a series of compounds and tested their radiosensitization effect on Hela-S 3 cells in vitro.