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实验结果表明,息肝灵对四氯化碳、硫代乙酰胺引起小鼠SGPT升高有明显的降低作用,相应的肝组织病变减轻,BSP潴留量明显减少:对正常小鼠的SGPT活力,无论体内或体外试验均无明显影响。此外,息肝灵对四氯化碳损害小鼠戊巴比妥钠睡眠时间均能明显缩短.息肝灵毒性较低,小鼠给60g生药/kgPO一次,连续观察七天,无出现中毒死亡;给二只犬灌胃18g生药/kgqd,连续15天,一般表现及病理检查脑、心、肝、脾、肾均无见异常.
The experimental results showed that the effect of Xiganling on carbon tetrachloride and thioacetamide caused a significant decrease in the elevation of SGPT in mice, the corresponding hepatic tissue lesions were reduced, and the BSP retention was significantly reduced: the SGPT activity in normal mice. No significant effect was observed in vivo or in vitro. In addition, Siganling can significantly shorten the sleep time of mice with sodium tetrachloride. The toxicity of pentobarbital sodium is significantly lower. The toxicity of sildenafil is lower. The mice are given 60g crude drug/kgPO once and continuously observed for seven days without any poisoning death. Two dogs were gavaged with 18g crude drug/kgqd for 15 consecutive days. There was no abnormality in general performance and pathological examination of brain, heart, liver, spleen, and kidney.