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测定ａｚｉｔｈｒｏｍｙｉｎ（ＡＺＭ）体外抗菌作用，以红霉素（ｅｒｙｔｈｒｏｍｙｃｉｎ，ＥＭ）为对照，并与其它几种大环内酯类抗生素进行了比较，结果表明国产ＡＺＭ对ＥＭ敏感的革兰氏阳性菌的抗菌作用与ＥＭ相似，ＭＩＣ９０在０．５～４．０ｍｇ／Ｌ范围内；对淋病奈瑟氏菌及流感嗜血杆菌的ＭＩＣ９０均为２ｍｇ／Ｌ，为ＥＭ的１／４；对大肠菌和肺炎克雷伯氏菌抗茵作用则明显优于ＥＭ。本品对金葡球菌无杀菌作用，浓度为０．５及０．２５ｍｇ／Ｌ时，对化脓性链球菌及肺炎球菌表现出较强的杀菌作用，并明显优于ＥＭ。
The antibacterial activity of azithromyin (AZM) in vitro was determined. Erythromycin (EM) was used as a control and compared with several other macrolide antibiotics. The results showed that the susceptibility of AZM to Gram-positive bacteria The antibacterial activity is similar to that of EM, MIC90 is in the range of 0.5-4.0 mg / L, MIC90 of Neisseria gonorrhoeae and Haemophilus influenzae is 2 mg / L, which is 1/4 of that of EM, Klebsiella pneumoniae anti-inflammatory effect was significantly better than EM. This product has no bactericidal effect on Staphylococcus aureus. When the concentration is 0.5 and 0.25mg / L, it shows strong bactericidal effect against Streptococcus pyogenes and pneumococcus, and is obviously superior to EM.