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介绍了含硫多肽类抗生素诺西肽（ｎｏｓｉｈｅｐｔｉｄｅ）产生菌Ｓ．ａｃｔｕｏｓｕｓ的诱变谱系及诺西肽发酵条件的研究。经紫外照射处理及自然分离获得的诱变菌株Ｚ＿（１０），其在适当的通气条件下培养，补入１％葡萄糖和２．５‰硫酸钠，诺西肽产量可达１０００μｇ／ｍｌ左右，比野生株原始产量提高１０倍。本研究为诺西肽工业生产奠定了基础。
Introduced the sulfur-containing polypeptide antibiotic nosiheptide to produce bacteria S. Actosus mutagenic lineages and nosiheptide fermentation conditions. The mutagenized strain Z_ (10) obtained by UV irradiation and natural separation was cultivated under appropriate aeration conditions, supplemented with 1% glucose and 2.5% sodium sulfate. The yield of nosiheptide reached about 1000μg / ml, The original production of wild strains increased by 10 times. This study laid the foundation for industrial production of nosiheptide.