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1971年,Sele等阐述初潮与第二性征的发生年龄皆属正常范围,身体发育亦无异常,但在30岁以前即出现继发性闭经,以后亦持续闭经,而将这种症例命名为早发卵巢不全症(Premature ovarian failure)。此时其促性腺激素呈高值,雌激素为低值,卵巢内尚存有未赋活的始基卵泡,并认为这类闭经为续发性闭经的5%。近几年来,有很多与本病病因有关的激素分泌动态测定的研究。Duignan等曾就10例患者进行了详细的研究。血中FSH值为61±6单位/立升较
In 1971, Sele et al. Described the age at onset of menarche and secondary sexual characteristics as normal range and no abnormalities in body development. However, secondary amenorrhea appeared before the age of 30 and subsequently amenorrhea, which was named as Premature ovarian failure. At this point its high value of gonadotropin, low estrogen, ovarian persistence of primordial follicles still exist, and that such amenorrhea for 5% of amenorrhea. In recent years, there are many studies on the dynamic measurement of hormone secretion related to the etiology of this disease. Duignan et al. Conducted a detailed study of 10 patients. Blood FSH value of 61 ± 6 units / liters compared