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本文作者从1964—1972年间芬兰的先天畸形登记的2784例中和相同数目的对照组进行了研究,以便发现哪些母亲在妊娠期曾应用过三环抗抑郁剂。妊娠期服用丙咪嗪可能引起有害的结果已被人们所注意。由于缺乏足够的资料,难以做出肯定的结论。作者们发现五例妊娠期服用三环抗抑郁剂的母亲出生畸形婴儿,四例头面部软组织或中枢神经系统畸形,一例为先天的多发性骨畸形。三例在妊娠早期曾应用过丙咪嗪和Chloropyramine(一种抗组织胺药物),另二例分别在妊娠早期与晚期用过阿密替林,对照组中仅一例用过阿密替林,均未用丙咪嗪。这个发现支持了丙咪嗪与先天畸形之间有着因果
The authors studied 2784 patients with the same number of controls registered during the 1964-1972 congenital malformations in Finland in order to find out which mothers used tricyclic antidepressants during pregnancy. It has been noticed that taking imipramine during pregnancy may have detrimental effects. Due to the lack of sufficient information, it is difficult to make any definitive conclusions. The authors found five infants born to mothers with tricyclic antidepressants during pregnancy, four with deformities of the head, facial soft tissue or central nervous system, and one with congenital multiple bone deformities. Three had imipramine and Chloropyramine (an antihistamine) in the first trimester of gestation and the other two used amitriptyline in early and late gestation and only one in the control group had amitriptyline, None of imipramine. This finding supports the causal relationship between imipramine and congenital malformations