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测定４７例食管癌患者的肿瘤及其邻近组织的端粒酶活性，并与其中２０例距肿瘤＞１０ｃｍ的正常食管组织做对照。结果显示，食管癌组织端粒酶阳性３９例（占８３％），邻近食管组织阳性３例（３／１７，占１７．６％）；对照组无阳性者。不同临床分期和组织学分级食管癌标本的端粒酶活性各异，其中１２例淋巴结转移癌灶中，食管癌端粒酶均为阳性。提示食管癌端粒酶活性较高，端粒酶在食管癌的发生、发展中起重要的作用
The telomerase activity was measured in 47 cases of esophageal cancer patients and their adjacent tissue, and compared with 20 cases of normal esophageal tissue >10cm away from the tumor. The results showed that 39 cases of telomerase were positive in esophageal cancer tissues (83%), and 3 cases (3/17, 17.6%) were positive in adjacent esophageal tissues. There were no positive cases in the control group. The telomerase activities of esophageal cancer specimens were different in different clinical stages and histological grades. Twelve cases of lymph node metastases were positive for telomerase in esophageal cancer. It suggests that telomerase activity is higher in esophageal cancer and telomerase plays an important role in the occurrence and development of esophageal cancer.