论文部分内容阅读
对２５例重度充血性心力衰竭（ＣＨＦ）患者在地高辛治疗前后测定血浆去甲肾上腺素（ＮＥ）及心率变异（ＨＲＶ）。结果显示：ＮＥ基础值与ＨＲＶ时域指标基础水平均呈负相关（Ｐ＜０．０５或＜０．０１）。地高辛治疗前后的ＮＥ相比（２９１±８０ｐｇ／ｍｌｖｓ２１３±８２ｐｇ／ｍｌ），Ｐ＜０．００１。２４小时平均ＲＲ间期及２４小时正常ＲＲ间期标准差由治疗前的７２７±１２３ｍｓ及６７．７±２１．８ｍｓ分别增加至７７７±１２２ｍｓ及８７．２±２９．２ｍｓ（Ｐ均＜０．０５）；２４小时相邻ＲＲ间期差值的均方根（ＲＭＳＳＤ）、２４小时正常相邻ＲＲ间期之差大于５０ｍｓ的心搏数所占百分比（ＰＮＮ５０）及高频（ＨＦ）由治疗前的３６．３±３０．６ｍｓ、５．３±５．５％及３７．１±２１．２ｍｓ２分别增加至５６．１±４３．７ｍｓ、１０．８±１０．６％及７９．９±５８．２ｍｓ２（Ｐ值＜０．０５至＜０．０１）；低频（ＬＦ）由治疗前的１１８．９±１３３．２ｍｓ２增加至１７１．２±１７２．８ｍｓ２（Ｐ＜０．００５）；ＮＥ下降幅度与时域指标增加幅度均呈正相关。ＨＲＶ多数时域指标增加幅度及其绝对值与血清地高辛浓度呈正相关，以ＲＭＳＳＤ和ＰＮＮ５０尤为显著（Ｐ?
Plasma norepinephrine (NE) and heart rate variability (HRV) were measured before and after digoxin treatment in 25 patients with severe congestive heart failure (CHF). The results showed that the basal value of NE was negatively correlated with the basal level of HRV time domain (P <0.05 or <0.01). Before and after digoxin treatment compared with NE (291 ± 80 pg / ml vs 213 ± 82pg / ml), P <0.001.24 hours mean RR interval and 24-hour RR interval standard deviation from 727 ± 123ms before treatment and 67.7 ± 21.8ms increased to 777 ± 122ms and 87.2 ± 29.2ms respectively (all P <0.05). RMSSD of 24-hour RR interval was normal at 24 hours The percentage of PNN50 and HF between the adjacent RR interval of more than 50 ms were significantly lower than those before treatment (36.3 ± 30.6 ms, 5.3 ± 5.5% and 37.1 ± 21.2ms2 increased to 56.1 ± 43.7ms, 10.8 ± 10.6% and 79.9 ± 58.2ms2 respectively (P <0.05 to <0.01); low frequency The former 118.9 ± 133.2ms2 increased to 171.2 ± 172.8ms2 (P <0.005). The decrease of NE was positively correlated with the increase of time domain index. The most significant increase in HRV and its absolute value were positively correlated with serum digoxin concentration, especially RMSSD and PNN50 (P =