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为了探讨乙型、丙型肝炎病毒感染在肝癌发展过程中的作用及两种病毒重叠感染对肝病恶性化的影响。我们采用聚合酶链反应技术和ＥＬＩＳＡ法检测了５２例原发性肝细胞癌患者血清乙型肝炎病毒脱氧核糖核酸（ＨＢＶＤＮＡ）及抗丙型肝炎病毒（ＨＣＶ），阳性率分别为７５０％，３８５％。二者重叠感染率为２８８％。并选择５４名急性肝炎患者血清作对照，检出率为４４０％，２２２％，５５％。本实验结果提示，乙型肝炎病毒感染在我国原发性肝细胞癌发生中起着主要作用，丙型肝炎病毒尤其是两种病毒重叠感染对肝病的慢性化、严重化、癌变存在着不可忽视的影响
In order to investigate the role of hepatitis B and C virus infection in the development of liver cancer and the effect of overlapping infections of two viruses on the malignancy of liver disease. We detected HBV DNA and hepatitis C virus (HCV) in 52 patients with primary hepatocellular carcinoma by polymerase chain reaction and ELISA. The positive rates were 75.0%. , 385%. The overlap infection rate between the two was 28.8%. The serum of 54 patients with acute hepatitis was selected as a control. The detection rate was 44.0%, 22.2%, and 5.5%. The results of this experiment suggest that hepatitis B virus infection plays a major role in the occurrence of primary hepatocellular carcinoma in China. Hepatitis C virus infection, especially two viruses, can not ignore the chronicity, severity, and canceration of liver disease. Impact