Autophagy and its neuroprotection in neurodegenerative diseases

• 作 者: Ping Gu Avaneesh Jakkoju Mingw
• 机 构: DepartmentofNeurology,DepartmentofNeurology,InstituteofNeurology
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2011年23期
• 关键词: 神经退行性疾病 神经保护作用 自噬 神经细胞死亡 细胞损伤 错误折叠 老年痴呆症 帕金森氏病 Autophagy neuroprotection neurode
• 基金项目: Supported by： Research Grants from the National Nature Science Foundation of China, No. 30970925＂, 30730096＂, and from Shanghai Pujiang Project, No. 09PJD014

It has been suggested that protein misfolding and aggregation contribute significantly to the development of neurodegenerative diseases.Misfolded and aggregated proteins are cleared by ubiquitin proteasomal system (UPS) and by both Micro and Macro autopha