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目的:比较不同胰岛素给药方法治疗年龄>60岁的老年2型糖尿病的有效性和安全性。方法:CSII(持续皮下胰岛素注射)组50例。MDI(多次皮下胰岛素注射)组46例,均进行短期胰岛素强化治疗,比较2组血糖水平,血糖达标时间,达标时胰岛素用量,低血糖发生率等。结果:CSII组达标时间为4.2±1.4天,MDI组为12.6±3.2天,CSII组明显较快(P<0.01);且2组低血糖的发生率无显著性差异(P>0.05)。结论:CSII治疗更符合生理状态下胰岛素分泌,证实在老年T2DM治疗中CSII能更快,更有效的控制血糖,且低血糖风险无明显增加。
OBJECTIVE: To compare the efficacy and safety of different insulin dosage regimens in the treatment of type 2 diabetes in elderly patients> 60 years of age. Methods: CSII (continuous subcutaneous insulin injection) group of 50 cases. MDI (multiple subcutaneous insulin injection) group of 46 patients were treated with short-term insulin-intensive therapy, comparing two groups of blood glucose levels, blood glucose compliance time, the target insulin dosage, the incidence of hypoglycemia. Results: The standard time of CSII group was 4.2 ± 1.4 days, the MDI group was 12.6 ± 3.2 days, and the CSII group was significantly faster (P <0.01). There was no significant difference in the incidence of hypoglycemia among the two groups (P> 0.05). CONCLUSIONS: CSII treatment is more consistent with insulin secretion under physiological conditions and confirms that CSII can control blood sugar faster and more effectively in elderly T2DM patients with no significant increase in the risk of hypoglycemia.