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自1972年Manolov和Manolova报道了Burkitt淋巴瘤(BL)的特征性染色体异常t(8;14)相互易位以来,嗣后又陆续发现t(2;8),t(22;8),t(11;14),t(14;18)易位及6q-等异常,它们与淋巴瘤的分型和临床过程密切关联.分子遗传学的技术使得研究更加深入,在与易位有关的染色体上已发现了数个较重要的基因位点.如8q24的癌基因c-myc,14q32的IgH(免疫球蛋白重链)基因,2p11的κ轻链基因和22q11的λ轻链基因等,并重点探讨了c-myc等基因的分子构成,正常与易
Since Manolov and Manolova reported the reciprocal translocation of t(8;14), a characteristic chromosome abnormality of Burkitt lymphoma (BL), in 1972, t(2;8), t(22;8), t 11;14), t(14;18) translocations, and 6q- and other abnormalities, which are closely related to lymphoid typing and clinical processes. Molecular genetic techniques have led to deeper research on chromosomes associated with translocations. Several important gene loci have been found, such as c-myc oncogene 8q24, IgH (immunoglobulin heavy chain) gene on 14q32, κ light chain gene on 2p11 and λ light chain gene on 22q11, etc. The molecular structure of genes such as c-myc was investigated. Normal and easy