论文部分内容阅读
目的探讨α-萜品烯醇对弗氏完全佐剂诱导的大鼠佐剂性关节炎的作用及其机制。方法建立弗氏完全佐剂诱导的大鼠关节炎模型。用0.18,0.35,0.7 mg.kg 1的α-萜品烯醇进行治疗,同时设雷公藤多苷组(阳性对照组)、模型组和空白对照组。比较各组关节肿胀率变化,血清IL-4和IFN-γ含量及病变关节损害程度。结果α-萜品烯醇0.35,0.7 mg.kg 1组、雷公藤多苷组可减轻关节炎症状,降低关节肿胀率(P<0.01),调节IFN-γ、IL-4水平。结论α-萜品烯醇能有效改善大鼠关节炎症状,减轻关节肿胀率,降低IFN-γ水平,升高IL-4水平。
Objective To investigate the effects of α-terpineol on adjuvant arthritis induced by Freund’s complete adjuvant and its mechanism. Methods The model of arthritis induced by Freund’s complete adjuvant was established. 0.18,0.35,0.7 mg.kg 1 of α-terpineol alcohol treatment, at the same time set Tripterygium glycosides group (positive control group), model group and blank control group. The changes of swollen joint rate, serum IL-4 and IFN-γ levels and the degree of joint damage were compared between groups. Results Tripterygium alcohol group 0.35, 0.7 mg.kg 1, tripterygium glycosides group can reduce the symptoms of arthritis, reduce joint swelling (P <0.01), regulate the levels of IFN-γ, IL-4. Conclusion α-terpineol can effectively improve the symptoms of arthritis, reduce the swelling rate of joints, reduce the level of IFN-γ and increase the level of IL-4.