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目的观察舒尔通合剂止吐、对食管上皮增生的作用。方法家鸽静脉注射硫酸铜制作呕吐动物模型,舒尔通灌胃后观察药物防止呕吐的作用;手术方法制作大鼠食管反流模型,应用滴灌到胃的给药方法观察对大鼠食管上皮组织增生的影响。结果舒尔通合剂能对抗硫酸铜引起的家鸽的呕吐,与对照组比较呕吐次数及呕吐潜伏时间差异有统计学意义(P<0.01);HE染色显示舒尔通合剂能减少由于食管反流引起的上皮损伤。结论舒尔通合剂具有防止呕吐的作用,并能明显改善食管上皮由于反流造成的组织损伤。
Objective To observe Shure Tonghe antiemetic, the role of esophageal epithelial hyperplasia. Methods Domestic pigeons were injected intravenously with copper sulfate to make animal models of vomiting. Shuretong was given into the stomach to observe the effect of drugs on preventing vomiting. The esophageal reflux model was made by operation method and the effects of drip irrigation to the stomach were observed. The impact of hyperplasia. Results Shuretong Mixture was able to counteract the vomiting of pigeons caused by copper sulphate. There was significant difference in the number of vomiting and vomiting latency compared with the control group (P <0.01). HE staining showed Shuretong Mixture could reduce the vomiting due to esophageal reflux Caused by epithelial injury. Conclusion Shure Tong Mixture has the effect of preventing vomiting and can obviously improve the tissue damage caused by reflux of esophageal epithelium.