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动物实验发现产前使用已烯雌酚(DES)可增加小鼠雌性后代患子宫腺癌、卵巢囊腺癌的危险性。其机理尚不清楚。为此用初潮年龄作为DES对第三代生理功能影响的检查指标进行研究。 资料来源于50年代初芝加哥大学进行的DES临床实验。1600例多妊娠妇女采用双盲随机分为DES治疗组或安慰剂对照组。DES组及对照组从妊娠后第一次就诊起。每天服用常量的DES或安慰剂至妊娠第35周。其中805位妇女生产了女婴(DES组
Animal experiments found that prenatal use of diethylstilbestrol (DES) can increase the female offspring of mice suffering from uterine adenocarcinoma, ovarian cystadenocarcinoma risk. The mechanism is not clear. To this end with the age of menarche as the third generation of physiological function of DES check index. Data from the University of Chicago in the early 50’s DES clinical trials. A total of 1600 pregnant women with multiple pregnancies were randomized into either DES-treated or placebo-controlled groups. DES group and control group from the first visit after pregnancy. Take constant doses of DES or placebo daily until the 35th week of gestation. Of these, 805 women produced baby girls (DES group