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目的:研究泮托拉唑联合克拉霉素及左氧氟沙星对消化性溃疡的治疗效果以及不良反应。方法:将54例幽门螺旋杆菌感染的病人随机分成2组,每组各27例,其中治疗组:予泮托拉唑肠溶胶囊40mg、克拉霉素分散片500mg、以及盐酸左氧氟沙星胶囊0.2g,每日两次,规律治疗1周后,继续服用泮托拉唑肠溶胶囊40mg,每日一次,继续治疗3个星期。对照组:奥美拉唑肠溶胶囊20mg、克拉霉素胶囊250mg、甲硝唑片400mg,每日两次,联合治疗1周后,继续服用奥美拉唑20mg,每日一次,总共治疗3周。两组规律治疗4周后,复查胃镜及幽门螺旋杆菌,比较溃疡面的愈合情况和幽门螺旋杆菌的根除情况以及两种疗法的不良反应。结果:两组治疗后,溃疡面的愈合及幽门螺旋杆菌的根除情况无显著性,但对照组的不良反应显著大于治疗组(P<0.01)。结论:泮托拉唑联合克拉霉素及左氧氟沙星的三联疗法对幽门螺旋杆菌的根除率高、不良反应少,是一种安全实用的消化性溃疡治疗方案。
Objective: To study the therapeutic effect and adverse reaction of pantoprazole combined with clarithromycin and levofloxacin on peptic ulcer. Methods: 54 cases of Helicobacter pylori infection were randomly divided into 2 groups of 27 patients in each group, including the treatment group: pantoprazole enteric-coated capsules 40mg, clarithromycin dispersible tablets 500mg, and levofloxacin hydrochloride capsules 0.2g, Twice daily, regular treatment for 1 week, continue to take pantoprazole enteric-coated capsules 40mg, once daily, continue treatment for 3 weeks. Control group: omeprazole enteric-coated capsules 20mg, clarithromycin capsules 250mg, metronidazole tablets 400mg twice daily, combined treatment for 1 week, continue to take omeprazole 20mg once daily for a total of 3 week. Two groups of regular treatment for 4 weeks, review of gastroscopy and Helicobacter pylori, ulcer healing and Helicobacter pylori eradication were compared, as well as adverse reactions of the two therapies. Results: After the treatment, ulcer surface healing and H. pylori eradication were not significant, but adverse reactions in the control group were significantly greater than those in the treatment group (P <0.01). Conclusions: The triple therapy of pantoprazole combined with clarithromycin and levofloxacin has a high eradication rate and few adverse reactions to helicobacter pylori. It is a safe and practical treatment program for peptic ulcer.