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婴幼儿高胰岛素性低血糖症随着诊断技术的进步,已受到广泛重视.这种低血糖可是暂时性的,见于母亲患糖尿病、胎儿型红血球母细胞增多症(erythroblastosis fetalis)和Wiedemann-Beckwith综合症等;也可是持续性的,见于胰岛细胞腺瘤和胰岛母细胞增殖症(nesidioblastosis)等.持续性高胰岛素性低血糖较少见,但更加危险.对此以前认识不够,也几乎无法诊断,成为新生儿和婴幼儿不明原因死亡的一部分,也可造成儿童的精神发育障碍.早期诊断十分重要,当代的实验室技术已可在几天内提供诊断,最重要的诊断指标有:(1)血浆胰岛素水平高而血糖低.(2)静脉输注葡萄糖速率在每分钟15mg/kg以上才能维持血糖在36mg%以上.(3)低血糖合併低血酮体.(4)机体在低血糖时对胰高血糖素有良好升糖反应.随着对此病认识和检出率的提高,治疗的研究也
Infants and young children with hyperinsulinemic hypoglycemia have become widely recognized with the advancement of diagnostic techniques such as transient hypothyroidism seen in maternal diabetes, erythroblastosis fetalis and Wiedemann-Beckwith syndrome Can also be persistent, found in pancreatic islet cell adenoma and islet cell proliferation (nesidioblastosis), etc. Persistent hyperinsulinemic hypoglycemia is less common, but more dangerous, previously not recognized enough, and almost impossible to diagnose , As part of unexplained deaths in newborns and infants and young children, can also contribute to mental retardation in children. Early diagnosis is important and modern laboratory techniques are available to provide diagnosis within a few days. The most important diagnostic criteria are: (1 ) High plasma insulin levels and low blood sugar. (2) intravenous glucose infusion rate of 15mg / kg or more in order to maintain blood glucose above 36mg%. (3) hypoglycemia with hypokalemia. (4) body in hypoglycemia When glucagon has a good glycemic response with the understanding of the disease and the detection rate increased, the treatment of research is also