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许多作者曾注意到丙戊酸钠(VPA)和它的衍生物的肝脏毒性作用,也有报告癫癎患者单用或并用VPA引起致死性中毒性肝炎者.本文报告1例并经病理证实.28个月婴儿,1978年1月初诊,家族史、既往史无异常.数月前曾发生肌阵挛失神发作.对光特别敏感,发作频率随不同季节光线强度而不同.冬季发作较少,春、夏发作频繁,在强光下可诱起反复发作.EEG检查时,间歇性光刺激可诱发弥漫性多棘—慢波,偶尔有强直—阵挛大发作.神经、精神检查正常,血尿、CSF气相色谱分析均正常,血和骨髓未发现粘多糖及空泡淋巴细胞,血及CSF中未发现病毒抗体,染色体检查及CT扫描
Many authors have noted the hepatic toxic effects of sodium valproate (VPA) and its derivatives, as well as reports of fatal toxic hepatitis in patients with epilepsy alone or in combination with VPA. Month-old baby, first visit in January 1978, family history, no history of normal past few months ago had myoclonic absence seizures. Particularly sensitive to light, seizure frequency varies with different seasons of light intensity less winter seizures, spring , Frequent summer seasons, in the light can be induced by repeated attacks.EEG examination, intermittent light stimulation can induce diffuse spine - slow wave, and occasionally tonic - clonus seizures .Nerve, mental examination was normal, hematuria, CSF GC analysis were normal, blood and bone marrow found mucopolysaccharide and vacuolar lymphocytes, blood and CSF antibodies were not found, chromosome examination and CT scan