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目的观察及研究氨基葡萄糖对类风湿关节炎(RA)致膝关节软骨损伤的临床疗效。方法选取2013年1月-2015年6月进行治疗的46例RA致膝关节软骨损伤患者,将其随机分为对照组(常规治疗)和研究组(常规治疗加氨基葡萄糖),各23例,比较两组患者治疗前后的Noyes分级及血清关节软骨损伤相关指标[软骨寡聚基质蛋白(COMP)、基质金属蛋白酶(MMP)-1、MMP-3及基质金属蛋白酶抑制因子(TIMP)-1]、炎性指标[肿瘤坏死因子(TNF)-α、白细胞介素(IL)-17及IL-33]。结果研究组在治疗后4、8、12周的Noyes分级构成均好于对照组,但组间差异无统计学意义(P>0.05);研究组在治疗后4、8、12周的血清COMP、MMP-1、MMP-3、TIMP-1、TNF-α、IL-17及IL-33均低于对照组,差异均有统计学意义(P<0.05)。结论氨基葡萄糖对RA致膝关节软骨损伤患者的关节软骨损伤及炎性应激状态均有积极的改善作用。
Objective To observe and study the clinical effect of glucosamine on knee cartilage injury induced by rheumatoid arthritis (RA). Methods From January 2013 to June 2015, 46 RA patients with knee joint cartilage injury were randomly divided into control group (conventional treatment) and study group (conventional treatment plus glucosamine), 23 cases in each group, Noyes grade and serum cartilage injury related index (cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP) -1, MMP-3 and TIMP-1] of two groups before and after treatment were compared. , Inflammatory indicators [tumor necrosis factor (TNF) -α, interleukin (IL) -17 and IL-33]. Results Noyes grading at 4, 8 and 12 weeks after treatment in the study group was better than that in the control group, but there was no significant difference between the two groups (P> 0.05) , MMP-1, MMP-3, TIMP-1, TNF-α, IL-17 and IL-33 were significantly lower than those in the control group (P <0.05). CONCLUSION Glucosamine has a positive effect on the injury of articular cartilage and inflammatory state in RA-induced knee joint cartilage injury.