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Dah1等指出,长期以来有关钠利尿的第3因子,认为是能抑制肾小管Na~+、K~+-ATP酶活性的激素样物质,此外,它也抑制心肌、血管平滑肌酶的活性,使钠储留于细胞内,由于钠、钾交换系统受抑制造成钾蓄积于细胞内,由此产生了心收缩力加强的效果,随之血管平滑肌张力增强引起高血压故称之为致高血压因子。未用过洋地黄的人,血中也测出地高辛免疫活性物质(DLI),其血、尿中的浓度和血压值有关,称它为第3因子或内因性洋地黄样物质。近年来,Blaustein与Upjohn协作,从大量肾上腺组织中分离出洋地黄样物质,分析其成分为洋地黄和乌木(箭毒)甙。由此
Dah1 pointed out that the third factor related to sodium diurea has long been considered as a hormone-like substance that inhibits tubular Na ~ + and K ~ + -ATPase activity. In addition, it inhibits the activity of myocardial and vascular smooth muscle enzymes, Sodium is stored in the cell, due to inhibition of sodium and potassium exchange system caused by the accumulation of potassium in the cells, resulting in enhanced cardiac contractility effect, accompanied by increased vascular smooth muscle tension caused by high blood pressure so called hypertensive factor . Digoxin-free immunoglobulins (DLI) have also been measured in blood as a marker of factor 3 or endogenous digitalis if they have not been used in digitalis. In recent years, Blaustein, in collaboration with Upjohn, has isolated digitalis-like substances from a number of adrenal glands and analyzed them for digitalis and ebony (arrow poison) glycosides. thus