慢性乙型肝炎血清HBV-DNA检测及临床意义

• 作 者: 王文治
• 出 处: 吉林医学
• 发表日期: 1988年01期
• 关键词: DNA 慢性乙型肝炎病 血清 分子杂交技术 乙型肝炎 检测 病人血清 滴度 含量测定结果 相关系数

应用分子杂交技术检测71例 HBsAg 阳性的各类慢性乙型肝炎病人血清 HBV-DNA 含量,同时检测其血清 HBeAg 阳性率及 HBsAg滴度。HBV-DNA 阳性者30例(占42.25%),结果表明 HBV-DNA 阳性率以慢活肝组最高,与带毒组相比差异非常显著(P<0.01)。30例 HBV-DNA 阳性病人血清 HBV-DNA含量测定结果表明,HBV-DNA 的含量与HBsAg 滴度呈正相关,相关系数 r=0.779。

The molecular weight of HBV-DNA in serum of 71 HBsAg-positive chronic hepatitis B patients was detected by molecular hybridization, and the serum HBeAg positive rate and HBsAg titer were also detected. HBV-DNA positive in 30 cases (42.25%), the results showed that the positive rate of HBV-DNA in chronic active liver group was the highest, compared with the infected group, the difference was significant (P <0.01). The serum HBV-DNA levels in 30 HBV-DNA positive patients showed that the content of HBV-DNA was positively correlated with the HBsAg titer, with a correlation coefficient of 0.779.