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以大鼠为实验对象，测定安静时、大强度间歇负重游泳运动后即刻及运动后休息４５分钟时血浆血栓烷Ｂ_２（ＴＸＢ_２）、６－酮－前列腺素Ｆ_（１２）（６－ｋｅｔｏ－ＰＧＦ_（１２））的浓度变化及尿总蛋白（ＴＰ）、白蛋白（Ａｌｂ）、β_２微球蛋白（β_２－ｍＧ）排泄率变化，以期为运动后蛋白尿的生成机制提供实验材料。结果表明：运动后即刻血浆ＴＸＢ_２、６－ｋｅｔｏ－ＰＧＦ_（１２）明显高于对照组（Ｐ＜０．０５；Ｐ＜０．０１），尿ＴＰ、Ａｌｂ、β_２－ｍＧ排泄率也呈非常显著的升高。运动后休息４５分钟时血浆ＴＸＢ_２及尿ＴＰ、Ａｌｂ、β_２－ｍＧ均呈不同程度的减少。相关分析表明ＴＸＢ_２、ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_（１２）比值与尿ＴＰ、Ａｌｂ、β_２－ｍＧ之间呈高度正相关；虽然６－ｋｅｔｏ－ＰＧＦ_（１２）与尿ＴＰ、Ａｌｂ、β_２－ｍＧ之间呈负相关，但无明显统计意义（Ｐ＞０．０５）。提示血栓素，前列环素的变化可能是运动后蛋白尿生成机制中的一个重要因素。
The rats were used as experimental subjects. When resting at high intensity intermittent load-bearing swimming and rest 45 minutes after exercising, the plasma levels of TXB_2, 6-keto-PGF_ (12) (12), and the changes of urinary total protein (TP), albumin (Alb) and β_2-microglobulin (β_2-mG) excretion rate in order to provide experimental materials for the mechanism of proteinuria after exercise. The results showed that the plasma levels of TXB_2, 6-keto-PGF_ (12) immediately after exercise were significantly higher than those in the control group (P <0.05; P <0.01) Increase. Resting 45 minutes after exercise when the plasma TXB_2 and urinary TP, Alb, β_2-mG were decreased to varying degrees. Correlation analysis showed that the ratio of TXB2, TXB2 / 6-keto-PGF12 and urine TP, Alb, and β2-mG were highly positively correlated. Although the correlation between 6-keto-PGF12 and urinary TP, Alb, However, there was no statistical significance (P> 0.05). It is suggested that the change of thromboxane and prostacyclin may be an important factor in the mechanism of proteinuria after exercise.